Kalbitzer Innovations UG
Kalbitzer Innovations is a spin-off from the Institute of Biophysics and Physical Biochemistry of the University of Regensburg that provides novel experimental and computational methods. Actually it is focused on the development of project specific software for the application of complex analytical methods such as NMR-spectroscopy and the use of high hydrostatic pressures up to 500 MPa in biomedicine, especially in drug development and protein biotechnology.
Core Technologies and Services
Software Development: Kalbitzer Innovations develops software for specific application in analytics, in particular in NMR based analytics. An important product is the software package AUREMOL that is developed in cooperation with Bruker BioSpin and the University of Regensburg and is distributed by Bruker Biospin GmbH. It contains functions for computer-aided automated NMR spectrum evaluation, protein structure determination and quality control.
Application of High Hydrostatic Pressures in Biotechnology: The application of high pressures in biotechnology and drug development provides novel possibilities since especially conformational equilibria and reaction rates are strongly pressure dependent. Typically high pressures up to 500 MPa are used that would correspond to a water pressure at 50,000 m below sea level (the deepest point known in the oceans is 10,994 m). In cooperation with Pressure BioSciences Inc. Kalbitzer Innovations is developing sophisticated hardware and software for integrating high pressure set-ups in NMR spectrometers.
Patents, Licenses, Co-operations
•University of Regensburg: Institute of Biophysics and Physical Biochemistry, Regensburg
•Bruker BioSpin GmbH, Karlsruhe
•Pressure BioSciences (PBI) Inc., South Easton, MA