FOR 2127 - Selection and adaptation during metastatic cancer progression
Aim of the Research Unit is a systematic analysis of systemic cancer progression. We will focus on evolutionary processes that drive colony formation and growth of a metastasis as well as the development of drug resistance. We will investigate how cancer cells escape intrinsic (cellular failsafe) as well as extrinsic control mechanisms during metastasis. To this end, the different partners will provide state-of-the-art technologies to study genomic, epigenomic and transcriptomic alterations, which allow a comprehensive assessment of cellular deregulation. These alterations will then be put into context of cellular lineage trees that we will generate for individual patients or mice.
GRK 1910 - Medical Chemistry of Selective GPCR Ligands
Approximately 30 % of the drugs on the market exert their biological activities upon binding to G-protein coupled receptors (GPCRs). Severe diseases are frequently associated with dysfunctions of GPCRs. The proposed Research Training Group aims to explore the ligand induced control of monoaminergic and peptidergic GPCRs at aforementioned levels of selectivity. In addition to the elucidation of molecular mechanisms, we attempt to contribute to a rational development of functionally selective GPCR drugs for the treatment of chronic inflammatory, cardiovascular and CNS diseases and for diagnostic purposes.
GRK 2174 - Neurobiology of Emotion Dysfunctions
The Graduate Programme Neurobiology of Emotion Dysfunction (GRK) at UR provides outstanding German and international doctoral students with a specialized and nevertheless interdisciplinary programme at the highest conceptual and methodological level. The students perform well-focused projects aimed to reveal multiple aspects of emotional behaviours in health and disease across molecular, neuronal, neuroendocrine and be-havioural levels in an appropriate research environment.
KFO 243 - Early Immunological Determinants of Late Transplant Outcome
In the KFO 243 ELITE project, "Early Immunological Determinants of Late Transplant Outcome" scientists and clinicians from various interdisciplinary research groups at the University of Regensburg work closely together under the direction of Professors Hans Schlitt and Edward Geissler (both Department of Surgery). The project is dedicated to investigating the early molecular and cellular immunological factors that determine the long-term success of transplanted allografts to develop novel therapeutic strategies to control and monitor pathologic post-transplant alloreactivity.
KFO 262 - Tumor Metabolism as modulator of immune response and tumor progression
The clinical research unit KFO 262 "Tumor metabolism as modulator of immune response and tumor progression aims to clarify how to best target these unique metabolic dependencies of tumor cells for therapeutic benefit and to identify drugs and diagnostic biosignatures for cancer therapy.
SFB 699 - Strukturelle, physiologische und molekulare Grundlagen der Nierenfunktion
The aim of the Collaborative Research Centre is to proceed with the understanding of kidney function on the molecular, cellular and integrative level. We expect from this strategy a better understanding of the pathophysiology of the kidney forming the basis for the prevention or causal therapy of kidney disease. The projects within this Collaborative Research Centre usually follow a common approach spanning from the gene over the isolated organ to the whole organism. Genetically engineered mice will serve as models for the study of pathophysiological aspects. If possible, studies should also be extended onto humans.
SFB 924 - Molecular mechanisms regulating yield and yield stability in plants
The Collaborative Research Centre consortium brings together experts from different biological research fields that make use of high throughput technologies supported by bioinformatics and proteomics to resolve the molecular mechanisms that regulate yield and yield stability in plants. Research of the participating groups focuses on processes that regulate reproductive success as well as quantitative and qualitative aspects of seed formation (yield regulation). A second project area concentrates on the molecular mechanisms governing the interactions of plants with their abiotic and biotic environment (yield stability).
SFB 960 - Ribosome formation: principles of RNP biogenesis and control of their function
Proteins and ribonucleic acids associate to a large number of macromolecular complexes (ribonucleoprotein complexes, RNPs) in living cells. Many of them are acting together as crucial players in numerous biological networks. Consequently, impaired RNP formation and function are linked to cellular malfunction and severe disease. Accordingly, analyses of dynamic RNP-assembly processes and the regulation of RNP function became central topics in recent research. Ribosomes form the centre of our investigations. We propose to analyse the many overlapping processes leading to mature ribosomes, compare them with the formation of other RNPs and focus on their interaction with RNAs or other RNPs, which are important to control their activity.
FOR 1075: Regulation and Pathology of Homeostatic Processes for Visual Function
At the University of Regensburg, homeostatic systems are investigated in a multidisciplinary approach, with the final goal to uncover the reasons for cell death of neurons in the retina, and to develop novel and better therapeutic strategies. Members of the Research Unit are laboratories from three different faculties such as the faculty for natural sciences III (human anatomy), the medical faculty (ophthalmology, human genetics and neurology) and the philosophical faculty II (psychology).